One benign lymph node is present.Sickle cell disease is the name for a group of inherited health conditions that affect the red blood cells. Reactiveįibroblasts and hemosiderin-laden macrophages are present. (predominantly consisting of lymphocytes and plasma cells), and mucosal erosions. The sections shows gallbladder wall with edema, a moderate mixed inflammatory infiltrate Inflammatory infiltrate predominantly consisting of lymphocytes. The sections shows gallbladder wall with Rokitansky-Aschoff sinuses and a moderate mixed SMALL AMOUNT OF LIVER WITH CAUTERY/CRUSH ARTIFACT. CHRONIC CHOLECYSTITIS WITH MILD CHOLESTEROLOSIS. SMALL AMOUNT OF LIVER WITHOUT APPARENT PATHOLOGY. Liver present GALLBLADDER, CHOLECYSTECTOMY: Without stones GALLBLADDER, CHOLECYSTECTOMY: CD10 stains the luminal surfaces of epithelial cells, a finding that militates against dysplasia.īlock letters GALLBLADDER, CHOLECYSTECTOMY: Monoclonal CEA stains neutrophils, but not epithelial cells. Polarity is generally, but not always, preserved, with most nuclei at the base of the cell, with the longer nuclear dimension, when the nucleus is not round, being perpendicular to the luminal surface. Nuclei show variability in size and, to a lesser degree, shape. Neutrophils lie within cytoplasm of epithelium. Lymphoid follicles are associated with chronically inflamed plicae. The lack of cancerous nuclear change is important as well.Ĭhronic cholecystitis with reactive epithelial atypia in a 92 year old. The triple parallel tubules argue against neoplasia. The focus on the right is difficult to identify as lying between muscle bundles. There is no desmoplasia, but some gallbladder adenocarcinomas show little recognizable desmoplasia. Note again the predominant extension between muscle bundles, recognizable by the stroma about the sinuses, some of which are branched, pushing the muscle wall aside. The mucosa shows extensive reactive branching. Note the longitudinal extensions of the Rokitansky-Aschoff sinuses, as well as the ballooning outside the wall at lower right. In between the gall stone at lower left and the lymphoid aggregate at upper right lies the gallbladder wall. Note their travel in between muscle bundles can be recognized as continuity to the surface. Extending from a benign, chronically inflamed plicae are Rikitansky-Aschoff sinuses.
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